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Pharmaceutical and biopharmaThe leading incubators and climate chambers for pharmaceutical and biopharma industries

The leading incubators and climate chambers for pharmaceutical and biopharma industries

For researchers in the medical sciences and life science sectors, high-precision, accuracy and product safety are top priorities.

BINDER’s chambers are used by the pharmaceutical industry to test the shelf life of medicines, as well as to store and incubate cells under various climatic and lighting conditions.

These chambers can simulate a vast range of environmental situations with controlled humidity, temperature and light in order to test the resistance of drugs and ascertain how these conditions affect their properties.

Applications

  • Manufacture and analysis of active ingredients (drug industry), quality and shelf life specifications of drugs
  • Develop methods, validate methods, conduct stability tests
  • Stability tests according to ICH Guidelines
 
  1. Long-term stability test
  2. Accelerated stability test
  3. Intermedium stability test
  4. Stress test (stability test)
   
  • Stability tests according to ICH Q1A
  • Photostability tests according to ICH Q1 B
  • Stability tests of new drug substances at 40°C/75%RH
  • Drug discovery
  • Drug development
  • ADME-Tox
  • Clinical studies
  • Proteins (EPO, IFN, mAB)
  • Vaccines (Antigen)
  • Produce recombined proteins in an industrial scale
  • Produce active pharmaceutical ingredients (API)
  • Human skin reproduction
  • General -86°C cold storage applications
  • Long-term storage of drug substances at -86°C e.g. medicines against cardio-vascular diseases, metabolic disorders, immunology, infectious diseases, neurology and oncology
  • Biobanking storage of organic materials at -86°C e.g. epidemiology, pathogenic viruses and bacteria blood banks, erythrocytes and leucocytes

Recommended products:

  • Constant climate chamber/humidity test chamber

    BINDER humidity chambers stand out when testing material behaviors under constant temperature and humidity conditions.

    A humidity test chamber of the KBF P and KBF LQC Series also offers ICH-compliant illumination for standard-compliant long-term tests. In combination with the innovative Light Quantum Control (LQC), they offer a complete and reliable solution for photostability testing in one chamber.

    Wide temperature and humidity ranges can be achieved with KMF Series chambers – ideal for complex stress tests at, for instance, 85 °C and 85% RH.

    Links to below series on product database:
    | KBF, KBF-S, KBF-P, KBF-LQC

  • Ultra low temperature freezers

    Ultra low temperature freezers

    The spotlight is on environmentally-friendly design in the new BINDER ultra low temperature freezer. This applies particularly to the best energy efficiency in its class and the lack of refrigerants that are harmful to the climate. A multi-layered safety concept allows users to mix and match elements to suit any environment. With practical unit sizes appropriate, sophisticated options and practical accessories, users have everything they need for reliable long-term storage of highly sensitive samples.

Case studies and applications in research

Tracking cancer cells using nuclear magnetic resonance (NMR)

At the Institute of Biophysics and physical Biochemistry at the University of Regensburg, a team of researchers is using NMR spectroscopy to study the metabolism of tumor cells. The goal is to identify tumor initiating cells, to predict their development and to facilitate targeted treatments. A BINDER KB 240 climate chamber with gas supply plays an important role in the experiment setup.

Drug safety – a major issue in patient protection worldwide

The Central Institute for Drug Research of the Diapharm Group is the service laboratory responsible for quality control of its drug products. As the ICH test is a significant component in the process of certifying or registering a product, the institute leverages BINDER KBF Series to achieve optimal climate condition for drug stability test.

Skin transplants save lives – human skin cell cultures are incubated at DIZG in BINDER incubators for clinical use

The Biotechnology Division of DIZG is primarily engaged in making cultured autologous skin available to severely burned patients quickly and reliably. In 18 years, the institute has contributed to saving the lives of nearly 100 severe burn patients. To incubate human skin cell cultures, the institute uses several BINDER incubators of the CB150 series.

Cell cultivation without contamination

No other problem in cell culturing is as universal as microbial contamination. To avoid it, good sterile techniques and thorough culture handling are essential. This whitepaper compares different contamination control concepts for CO2 incubators from the user’s perspective. Contaminations cannot be completely avoided but cell culture equipment supports the user in keeping a good cell culture practice.

Institute for Regenerative Medicine works on making aging skin appear younger

The Bioscience Institute and Clinic are among the world's leading centers for regenerative medicine and specializes in autologous stem cell therapies. Every step of this complex process is performed in-house by the Institute. When it comes to extracting and storing stem cells, the Institute relies on climate chambers from BINDER because of its utmost safety and defined, constant conditions.

Successful reproduction of human skin cells

To date, producing human skin required significant effort and the fulfilment of the very strictest safety requirements. The process of skin cultivation must be carried out in a class A cleanroom, which is the highest safety class. Check out how BINDER incubator plays a key role in a large-scaled project commissioned by a university hospital in Switzerland aiming to make the process of human skin production much more efficient.

Cell cultivation: for and against particular technical solutions in CO2 incubators

The aim of cell culture is to achieve and maintain good cell growth and to attain appropriate cell differentiation. This involves taking numerous requirements into account and technically implementing them. The CO2 incubator or CO2/O2 incubator is a key element in cell culture. Various technical solutions are used to achieve the right temperature, humidity, CO2 and/or O2 concentration, and interior design. This white paper compares various commercially available solutions.

BINDER freezers do their part in coronavirus vaccine research

The University of Bern’s high-security laboratory in Mittelhäusern conducts long-term virus research involving dangerous pathogens such as coronavirus and foot and mouth disease. “BINDER freezers have become a stalwart of my work”, stated Swiss virologist Professor Volker Thiel. Check out the benefits of BINDER’s ultra-low temperature freezers.

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