Waters - LC/MS Instruments

RADIAN ASAP Direct Mass Detector

The Power of Knowing Now

Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times; integrating direct MS analysis can drive multiple system-wide efficiencies helping to achieve your operational goals. Combining flexibility, ease of operation and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.

• Simple operation and data interpretation
• Minimal sample preparation
• No separation required
• Real-time results and classification

ACQUITY QDa Mass Detector

Press On to Bring the Power of Mass Detection to Your Lab

With great detection power comes great possibility – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis.

• Intuitive operation
• More information from every sample
• Effortless integration
• Increased efficiency
• Resolving complexity

SQ Detector 2

Designed for the routine, prepared for the unexpected

Compatible with the broadest range of chromatography platforms and ionization sources, the SQ Detector 2 is the ultimate single quadrupole mass detector for chromatography.

• IntelliStart™ guarantees maximum system performance and usability for reproducible results
• A wide mass range enables uncompromised analysis of both low and high molecular weight species
• Versatile chromatographic options ensure compatibility with the broadest range of applications
• Universal Ion Source Architecture offers easy compatibility with the widest range of analytes

Xevo TQ-XS Triple Quadrupole Mass Spectrometry

One system. Every analyte. All the time.

Demands on analytical laboratories are changing and every laboratory needs to ensure it can keep pace with these changes. The Xevo^® TQ-XS offers:

• StepWave XS™ ion guide that provides increased sensitivity for challenging compounds.
• Enhanced detection system with six orders of linear dynamic range to ensure sensitivity is accessible.
• Tool-free probe design reduces the time taken for any routine maintenance and provides improved reproducibility between users.

Xevo TQ-S

A step change in sensitivity with the Xevo TQ-S

Designed for the most demanding quantitative UPLC-MS/MS applications. The ultimate in tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness, available to everyone due to the accessibility of the Xevo platform.

• Class leading sensitivity and robustness
• Qualitative information when you need it most
• Accelerated method development for sensitive and robust methods
• Reduces complexity, increases ease of use, and ensures the correct result every time
• The widest range of ionization capabilities today, future-proofing for the innovations of tomorrow

Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

High Performance from a Compact Design with Rapid, Reliable and Reproducible Quantitative Data

Revolutionary design has produced a tandem quadrupole instrument with a small footprint that delivers consistent low levels of quantitation with a wide dynamic range.

• Class-leading performance that can fit into any lab
• Quantify highly polar, ionic compounds in food
• Benefit from flexibility and compatibility across the board
• Robust performance, even with the most complex sample matrices

Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry

Transform your quantitative capabilities. Accessible reliable performance.

High performance quantitation, accessible to all. Routine testing doesn’t have to be limited – maximize your performance by expanding your analytes per injection and extending your validated concentration range, without increasing your lab footprint. Delivering purpose driven performance, so you can:

• easily acquire and review your quantitative data to meet your analytical and regulatory needs
• target more analytes per injection and cover a wider concentration range
• develop robust methods and easily set up your system for analysis

Xevo TQD Triple Quadrupole Mass Spectrometry

The rugged, robust and reliable Xevo TQD

The single vendor solution for routine quantitative UPLC-MS/MS applications, providing maximum accessibility to the sensitivity, selectivity and robustness needed to ensure maximum productivity with minimum effort.

• Maximum uptime through unparalleled robustness
• Accelerated method development for sensitive and robust methods
• Reduces complexity, increases ease of use, and ensures the correct result every time
• Maximize throughput with no compromise on quality
• The widest range of ionization capabilities today, future-proofing for the innovations of tomorrow

ACQUITY RDa Detector

Delivering SmartMS to the Masses

Increase productivity, improve data confidence and simplify routine accurate mass workflows with the new ACQUITY RDa Detector.

Compact, compliance-ready and easy-to-use, this LC-MS system ensures your entire laboratory can easily access high resolution mass measurements to instantly start working smarter, not harder.

Xevo G2-XS Tof Time-of-Flight Mass Spectrometry

Performance, robustness, and flexibility made accessible to everyone

For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.

• Maximum robustness with no compromise in performance
• Highest quality, most comprehensive qualitative and quantitative information
• Flexibility to adapt to changing needs
• Accessible to experts and non-experts alike
• Upgrade path to full QTof functionality

BioAccord LC-MS System for Biopharmaceuticals

The First Smart MS-Enabled Biopharma Solution

Engineered Simplicity

The BioAccord LC-MS System is the first SmartMS-enabled biopharmaceutical solution. This compact, self-optimizing system has a built-in health check that ensures the system is always generating data of the required quality.

The simplicity provided by SmartMS means that the BioAccord generates the same high-quality results whether you are an LC-MS expert or a new user.

SELECT SERIES Cyclic IMS

Ultimate power, ultimate performance. Redefine the boundaries of science.

Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.

• Extends the benefits of routine ion mobility
• Provides variable, high-resolution ion mobility separations
• Introduces the unique ability to perform ion mobility/ion mobility and IMSn experiments

Xevo G2-XS QTof Quadrupole Time-of-Flight Mass Spectrometry

eXtreme Sensitivity, eXtraordinary Selectivity, eXceptional Solutions

For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.

• Maximum robustness with no compromise in performance
• Class-leading real-world quantitative sensitivity
• Highest quality, most comprehensive qualitative information
• Flexibility to adapt to changing needs
• Accessible to experts and non-experts alike

Vion IMS QTof Ion Mobility Quadrupole Time-of-flight Mass Spectrometry

Beyond Resolution

Do you have the vision to see what others don’t see? The risk of not seeing everything in your sample – or not seeing everything clearly - can be high, especially if this results in incorrect identifications or time-consuming additional confirmatory experiments. Vion IMS QTof dramatically reduces this risk as it has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling you to:

• Reduce the risk of missed metabolites in DMPK analyses
• Overcome complex and complicated matrices in food analysis
• Generate high-quality peptide mapping data for Biopharma

SELECT SERIES Cyclic IMS

Ultimate power, ultimate performance. Redefine the boundaries of science.

Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.

• Extends the benefits of routine ion mobility
• Provides variable, high-resolution ion mobility separations
• Introduces the unique ability to perform ion mobility/ion mobility and IMSn experiments

SYNAPT G2-Si High Definition Mass Spectrometry

Redefining Resolution - Resolution in 3 Dimensions

Information. Informatics. Impact. SYNAPT provides the most complete characterization of complex mixtures and molecules with unique levels of MS performance, industry leading informatics and unparalleled platform versatility.

• Superior separation with high-efficiency T-Wave IMS
• Ultimate UPLC-MS/MS performance
• Data independent & data dependent T-Wave IMS solutions
• CID and ETD fragmentation capabilities
• Wide range of experimental options

MALDI SYNAPT G2-Si High Definition Mass Spectrometry

Redefining Resolution - Resolution in 3 Dimensions

MALDI SYNAPT G2-Si is a uniquely powerful and versatile MS platform. It's the only way to combine multiple dimensions of separation for analysis of complex samples, from imaging to biological research to chemical materials characterization.

• High Performance, Accurate Mass MALDI MS/MS
• Superior post-ionization separation with T-Wave IMS
• High Definition Imaging (HDI) MALDI workflows
• Versatile Experimental Options
• Ultimate UPLC-MS/MS Performance

Vion IMS QTof Ion Mobility Quadrupole Time-of-flight Mass Spectrometry

Beyond Resolution

Do you have the vision to see what others don’t see? The risk of not seeing everything in your sample – or not seeing everything clearly - can be high, especially if this results in incorrect identifications or time-consuming additional confirmatory experiments. Vion IMS QTof dramatically reduces this risk as it has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling you to:

• Reduce the risk of missed metabolites in DMPK analyses
• Overcome complex and complicated matrices in food analysis
• Generate high-quality peptide mapping data for Biopharma

ionKey/MS

Enhanced MS with the Turn of a Key

The ionKey/MS System redefines ultimate performance by integrating microflow UPLC directly into the source of the mass spectrometer.  This provides an increased level of sensitivity, chromatographic performance, and ease-of-use that cannot be achieved any other way.

• The 150 µm I.D. iKey Separation Device achieves up to 40X increase in sensitivity compared to 2.1 mm UPLC columns
• The 300 µm I.D. iKey HT Separation Device allows higher sample throughput with short cycle times
• Simplified microflow LC-MS user experience
• UPLC separations with sub-2-µm particle technology
• Robust, reproducible, and reliable microflow LC-MS analyses

Waters Atmospheric Pressure Gas Chromatography (APGC)

APGC – No Compromise GC-MS

Waters Atmospheric Pressure Gas Chromatography (APGC) adds GC capability to today’s advanced MS technologies. This provides GC users with:

• High performance, ease of use allowing quick reaction to meet demands and increase throughput
• Access to ultra-trace quantification
• Comprehensive qualitative MS & MS/MS
• High-resolution ion-mobility separations

Atmospheric Solids Analysis Probe

Rapid Direct Analysis of Volatile and Semi-Volatile, Solid and Liquid Samples

The Atmospheric Solids Analysis Probe* (ASAP) (introduced by McEwan et al) is a useful tool for the rapid direct analysis of volatile and semi-volatile, solid and liquid samples using atmospheric pressure ionization.

The ASAP technique utilizes the heated nitrogen desolvation gas to vaporize the sample and a corona discharge for sample ionization. This allows low polarity compounds not amenable to ESI, APcI and APPI to be ionized with a high degree of sensitivity. Furthermore complex mixtures can be analyzed without the need for any sample preparation.

SELECT SERIES MRT

All the benefits of time-of-flight technology. Redefined performance.

Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.

• Identify sample components confidently with routine ppb mass accuracy 
• Resolve nominally isobaric interferences with high mass resolution, at all scan speeds
• Reveal isotopic fine structure for unambiguous elemental compositions
• Achieve high data quality in both MS and MS/MS
• Simplify data archiving and rapidly process data with reduced data files sizes