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Pharmaceutical

With the increasing demand for the discovery and development of new safer medicines at a lower cost, manufacturers must keep pace with the rapid growth of research and technology methodologies.

The current industry trends towards regionalization and personalization of treatment approaches have stepped up demand for faster, more efficient and increasingly flexible solutions. As a result, pharmaceutical manufacturing must continue to drive the need for tighter process controls, more thorough processes and improve product understanding. Having robust and powerful research instruments remains the priority for pharmaceutical companies particularly generic producers in the emerging markets as they need to achieve the highest possible productivity at the lowest possible costs.

At DKSH, we understand the challenges and the requirements for successful product development. We are a solutions provider who combines scientific instruments along with our expertise and experiences. We support our customers in sample testing, development and optimization of existing methods at each stage of the pharmaceutical development and manufacturing process.

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Measurement types

Particle size distribution

Particle size analysis in the range 0.01-3500 microns. For nanoparticle analysis see dedicated section.

Morphology

Morphological analysis of particles in the range 0.5-10000 microns (size, shape and transparency of particles). Integrated Raman chemical analysis with MDRS (Morphologically Directed Raman Spectroscopy).

Nanoparticle characterization

Size, concentration and zeta potential anlysis of nano-systems using light scattering techniques such as DLS, ELS and NTA techniques.

Rheology, Viscosity and Powder Flowability

Viscosity measurement and visco-elastic properties characterization of liquid dispersions, complex fluids and semi-solid materials.

Stability analysis

Rapid and objective quantification of concentrated dispersion real stability using Multiple Light Scattering.

High pressure homogenizer

High pressure homogenizing technique to produce stable nanoemulsions, reduce particle size or molecular weight of polysaccharides, nanoencapsulation, de-agglomeration, etc.

Exosomes and EVs characterization

Multiparametric characterization of exosomes and EVs including Sizing, Concentration per size range, Count, Phenotyping, Cargo, Integrity, Purity, etc.

Biomolecular interactions

Biomolecular interactions of proteins, antibodies, nucleic acids, lipids and other biomolecules using ITC Microcalorimetry or BioLayer Interferometry BLI techniques.

Protein aggregate analysis

SEC is the standard method for protein aggregate analysis. The choice of pore size is related to the size of the molecule to be separated.

Elemental analysis

XRF provides both qualitative and quantitative information on a wide variety of sample types. It can quantify elements from beryllium (Be) up to americium (Am) in concentrations from 100% down to sub-ppm level.

Phase identification

Phase identification is the most important application of X-ray diffraction (XRD). It is not only applied on powder samples but also on polycrystalline solids, suspensions and thin films.

Polymer characterization

Gel permeation chromatography (GPC) that separates analytes on the basis of size, typically in organic solvents. The technique is often used for the analysis of polymers.

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