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Chromatography Systems

Choose the right solution for your analysis

Data is paramount in scientific research as evidence-based questions escalate. Answers require accurate measurements for precise results to obtain the data to make informed decisions.

Scientists across many industries rely on Waters LC and LC-MS platforms to identify and understand chemical components that help answer their important questions: Is the product safe? Can the disease be understood? Can I meet my regulatory requirements?

With Waters as your measurement partner, you’re sure to get the tailored solution you need to achieve your workflow and analysis requirements. Find out more about our Dependability, Flexibility, Performance, Specialty, and Purification LC solutions that are purpose-built for your priorities.

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HPLC

Whatever your application, Alliance HPLC, Breeze HPLC, Arc HPLC and AutoPurification systems offer you proven solutions for all of your HPLC requirements - for today and the future. These systems are synonymous with dependable, routine performance and versatility.

Alliance HPLC System

Alliance HPLC System

Defined by dependability - today, and in the future

  • Time-tested, flexible, and reliable workhorse for your HPLC separations
  • Integrated solvent and sample management with consistent system-to-system performance and high reproducibility
  • A history of continued system improvements ensures the hightest in HPLC performance
  • Simplify your daily LC system start-up with advanced software functionality

Breeze QS HPLC

Breeze QS HPLC

Reliable, Precise Results. Simple HPLC at its Best.

The Breeze QS HPLC System delivers routine analyses and robust performance day after day, providing the confidence you need to get the job done. Used in laboratories worldwide, chromatographers know that they’ll get reliable data in an easy-to-use platform.

With a choice of multiple components to build your own liquid chromatography system, and software that allows you to simplify the complete management of your chromatographic data, the Breeze QS HPLC System delivers world-class performance – affordably.

Arc HPLC System

Arc HPLC System

Accurate analysis for all

Ever-evolving regulations are impacting LC method approaches for product quality control and beyond. Count on the Arc HPLC System for high-efficiency separations and quality data to help meet your regulatory requirements with confidence. With the Arc HPLC, you can easily replicate and improve the performance of existing LC methods without compromising data quality, eliminating the burdens of older, less efficient LC systems for routine use. Rugged and dependable, Arc HPLC delivers the ideal balance of performance and value for right-the-first-time analysis and trusted test results:

  • Enhance performance without redeveloping your method
  • Run methods with greater robustness over traditional HPLCs
  • Easily replicate, adjust, and enhance existing HPLC methods with low analyte carryover, high injection precision, and high back pressure tolerance
  • Seamlessly receive transferred methods from other HPLC platforms, preserving analyte retention time and reproducibility of your analysis
  • Support compliance with Empower Chromatography Data System (CDS), the gold standard, compliant-ready software that facilitates data review, eliminates burdensome compliance documentation, and improves the overall quality of laboratory data

ACQUITY QDa Mass Detector

ACQUITY QDa Mass Detector

Press On to Bring the Power of Mass Detection to Your Lab

With great detection power comes great possibility – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis.

  • Intuitive operation
  • More information from every sample
  • Effortless integration
  • Increased efficiency
  • Resolving complexity

ACQUITY UPLC/UHPLC Systems

UPLCTM Technology was created especially for scientists who seek proven, reliable technology that simultaneously improves laboratory productivity, efficiency, and throughput. With its success demonstrated by thousands of peer-reviewed papers and application notes, and dramatic process improvements, leading companies and institutions around the world have standardized on UPLC/UHPLC for measurable scientific and business benefits.

ACQUITY Premier System

ACQUITY Premier System

Stop Looking and Start Seeing

The ACQUITY Premier System is the next evolution of the ACQUITY UPLC platform of liquid chromatography systems, which includes the ACQUITY UPLC H-Class PLUS and I-Class PLUS. Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY UPLC PLUS Series, the ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control.

The ACQUITY Premier System features novel MaxPeak High Performance Surfaces (HPS) technology, which effectively reduces non-specific adsorption losses due to metal interactions and provides:

  • Reduced analysis times
  • Improved peak shapes
  • Decreased reagent costs
  • Improved LODs and RSDs
  • Reliable quantitation
  • Lower system downtime

Arc Premier System

Arc Premier System

See clearly and consistently, with confidence.

Today’s scientists and lab managers need to confidently produce the most accurate, reliable and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily. 

The Arc Premier System features the new, innovative technology of MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interactions, without complicated mobile phases or laborious methods. The Arc Premier System sharpens chromatographic peaks for metal-sensitive compounds by eliminating secondary interactions from metals, resulting in:

  • Improved compliance from higher quality data
  • Faster, more reproducible, and accurate data integration
  • Shorter time from sample to result, without conditioning

MaxPeak Premier Solutions

MaxPeak Premier Solutions

The Universal Platform for Liquid Chromatography

When High Performance Liquid Chromatography (HPLC) wasn't keeping pace with your demands to analyze more samples, faster, and with better results, Waters introduced ACQUITY UPLC technology, advancing speed, sensitivity and resolution in chromatography. As your lab requirements continued to rapidly evolve, our technology has advanced to help you meet them. Our MaxPeak Premier Solutions are the most significant innovation in separations science in more than 15 years, designed to reduce variability associated with metal-sensitive analytes - without time-consuming tasks like system and column passivation.

Based on your input, MaxPeak Premier Solutions were developed to help solve some of the most complex challenges associated with unpredictable chromatography, to meet the needs of today and evolve to meet the needs of tomorrow.

ACQUITY PREMIER Solution - Separation science redefined. Again.

ACQUITY UPLC H-Class PLUS System

ACQUITY UPLC H-Class PLUS System

Performance that advances your lab

  • Improve laboratory productivity by transitioning methods to UPLC Technology
  • Improve the characterization of your most complex samples through enhanced resolution
  • Leverage advanced tools that simplify and streamline your method development workflow
  • Improve precision with state-of-the-art high pressure binary or quaternary solvent blending 
  • Increase the analytical value of your samples by leveraging optical and mass information
  • Match the need of your laboratory through support of your existing HPLC, UHPLC, and UPLC methods

ACQUITY UPLC H-Class PLUS Bio System

ACQUITY UPLC H-Class PLUS Bio System

Purpose built to characterize the complex

Increasing complexity of modern biotherapeutic characterization, monitoring, and quality control assays require even more demanding analytical techniques to accurately define and assess critical quality control attributes (CQAs) related to product safety, stability, and efficacy.

The ACQUITY UPLC H-Class PLUS Bio System provides the same high resolution, high sensitivity separations you have come to expect from UPLC Technology, with the flexibility and ruggedness to run all the chromatographic modes you require – ion exchange (IEX), size exclusion (SEC), hydrophilic interaction (HILIC), or reversed-phase – all on the same system.

The complete flow path is engineered with iron-free, bio inert materials, helping your lab extend the lifetime of your instrument and maintain optimal bioseparations performance.

ACQUITY UPLC I-Class PLUS System

ACQUITY UPLC I-Class PLUS System

Complex challenges, solved

With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS provides new possibilities of maximizing the resolution and sensitivity of your methods; enhancing the characterization of your samples, while improving productivity to advance the science of your laboratory.

Highly efficient, rapid separations are facilitated by industry-leading ultra-low dispersion and delay volume.

Ultra-efficient, narrow peaks enhance the sensitivity of any mass spectrometer to simplify the characterization of the most complex samples.

ACQUITY UPLC M-Class System

ACQUITY UPLC M-Class System

Let your LC inlet do the work for your nano- to microscale separations

  • System of choice for sample-limited applications in proteomics and biomarker discovery
  • Higher sensitivity for any MS
  • Maximum amount of data  from any sample
  • Less sample preparation volume and cost
  • Reduced solvent consumption
  • Increased dynamic range
  • Flexible configurations for HDX technology, 2D, and UV detection

Analytical SFC system

The ease of reversed phase meets the power of normal phase.

ACQUITY UPC2 System

ACQUITY UPC2 System

With the ACQUITY UPC2 System, the orthogonal capability of normal-phase LC has been elevated to a mainstream technique: Convergence Chromatography.

  • The chromatographic principles and selectivity of normal-phase LC
  • The ease-of-use and method development simplicity of reversed-phase LC
  • The use of gradients across the widest polarity range
  • Chiral and achiral separations in one system, with unequaled speed and confidence

PATROL UPLC Process Analysis System

Take control of your bottom line – get a better understanding of your process and your product

PATROL UPLC Process Analysis System

PATROL UPLC Process Analysis System

For the first time, bring automation and UPLC together for direct online connection to your process with Real-TIME LC

  • Ensure final product quality and improve process yields
  • Work with real-time information that provides a great understanding of the efficiency and quality of your processes
  • Best-in-class analyses designed specifically for in-process analysis
  • Rely on results that improve operational efficiency, deliver quantifiable ROI, and increase profits

ACQUITY Advanced Polymer Chromatography System

The Next Era in Polymer Separation

ACQUITY Advanced Polymer Chromatography System

ACQUITY Advanced Polymer Chromatography System

  • Highest-resolution, size-based separations for chromatographic polymer characterization
  • Improve data consistency and quality by enabling fast, daily calibration
  • Automate method development with advanced system technologies
  • Get more information about your polymer, faster than before

ACQUITY UPLC Systems with 2D LC Technology

2D LC technology for UPLC/UHPLC separations

ACQUITY UPLC Systems with 2D LC Technology

ACQUITY UPLC Systems with 2D LC Technology

ACQUITY UPLC Systems with 2D LC Technology offer the lowest dispersion system for maximum peak capacity with the most reliable, highest performing solvent managers and valve compartments on the market to ensure accuracy and precision of the entire assay.

  • Ready-to-use configurations to get you to successful 2D UPLC experiments faster, with less troubleshooting and more confidence
  • ACQUITY UPLC Systems and proven columns enable best-in-class selectivity and sensitivity

Purification Solutions and Preparative Chromatography

For Purification Challenges, the Prescription is Waters

Purification Solutions and Preparative Chromatography

Purification Solutions and Preparative Chromatography

Chemistry purification laboratories demand variable sample throughput capabilities. The evolving demands placed upon purification chemists require access to solutions that deliver efficiency and scalability with ease. What’s needed: a comprehensive and flexible portfolio that enables substantial increases in throughput and flexibility, with an added dose of system robustness.

Waters’ purification solutions cover a wide range of scale and configurability to meet today’s needs and tomorrow’s opportunities.

  • Aerospace
  • Agriculture
  • Automotive
  • Biopharmaceutical and Biotechnology
  • Chemical
  • Construction
  • Cosmetics & Personal Care
  • Defense
  • Die & Mould
  • Education & Academics
  • Electronics
  • Energy
  • Environmental
  • Food & Beverage
  • Luxury
  • Machinery & Manufacturing
  • Medical
  • Mining & Minerals
  • Oil & Gas
  • Optical
  • Paper & Wood
  • Pharmaceutical
  • Polymers, Plastics and Rubbers
  • Powders & Pigments / Coating
  • Printing & Packaging
  • Railway
  • Semiconductor, Solar & Electronics
  • Service
  • Shipbuilding
  • Textile
  • Wholesale & Retail
WatersWaters Corporation, the world's leading specialty measurement company, has pioneered chromatography, mass spectrometry and thermal analysis innovations serving the life, materials and food sciences for nearly 60 years. With approximately 7,000 employees worldwide, Waters operates directly in 31 countries, including 15 manufacturing facilities, and with products available in more than 100 countries. Waters Corporation's businesses include Waters, TA Instruments, VICAM, ERA, and Nonlinear Dynamics. Waters creates business advantages for laboratory-dependent organizations by delivering ultra performance liquid chromatography (UPLC), high-performance liquid chromatography (HPLC), chromatography columns and chemistry products, mass spectrometry systems, laboratory informatics solutions, and comprehensive service programs to enable significant advancement in healthcare delivery, environmental management, food safety, and water quality.
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